Working with spot colours in desktop publishing seems like it should be a straightforward process. In practice, however, there are many potential pitfalls that have to be avoided to produce successful spot colour artwork.
First let's look at how spot colour printing works. First of all it is not like full colour printing. In full colour printing, four colours (cyan, magenta, yellow & black) are used in hundreds of thousands of possible combinations to create full colour printing. In spot colour printing, single colours of ink are used that limit the possible colour combinations to those specific inks. For example, if you had a spot colour job that was being printed in blue ink, the only variations in colour you will see is where the ink has been "screened" to give the appearance of a lighter shade. If you are printing with two colours, you are limited to those two colours and the lighter shades available through screening those two colours.
While there are some limitations of spot colour printing, there are also some advantages over full colour printing:
One of the biggest challenges in creating documents for spot colour printing with 2 or more colours is keeping your spot colours specified correctly within your software. To illustrate this point, let's use the example of a flyer that is printed with red & blue inks.

*Pantone ink swatch books generally contain samples on coated (glossy) paper and a separate section with samples printed on uncoated (matte) paper. The actual ink is the exact same whether it goes on coated or uncoated paper. After 10 years in the industry, I have yet to find a compelling reason why software manufacturers give the option of coated (cvc) or uncoated (cvu) within their software (as it is irrelevant in most regards until the job is actually printed).
Another issue that must be addressed prior to setting up your spot colour print job is whether you will use "quick printing" methods or "tight registration/traditional" methods.
In getting the most out of your spot colour printing, you should learn how to use screens effectively. A one colour print job with the colour being printed in a variety of different shades (ie. 20%, 40%, 60%, 80% & 100%) can have the same effect as multiple colours. A word of caution, however, is that not all colours screen as you might expect. For instance, there is no such thing as a light red. When red is screened back, it becomes pink (which may not be what you had in mind). Most printers have a Pantone book that shows different screen values of Pantone colours. Ask to have a look at this book before you set up your project so you can get predictable results.
We strive to be as accurate and current with our information as possible. Due to the infinite number of scenarios that occur in print & document creation, we can not guarantee that the above information will be correct in all situations.